Motif ID: FOX{D1,D2}.p2

Z-value: 1.213


Transcription factors associated with FOX{D1,D2}.p2:

Gene SymbolEntrez IDGene Name
FOXD1 2297 forkhead box D1
FOXD2 2306 forkhead box D2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXD1chr5_-_72744351-0.193.1e-01Click!
FOXD2chr1_+_47901688-0.096.3e-01Click!


Activity profile for motif FOX{D1,D2}.p2.

activity profile for motif FOX{D1,D2}.p2


Sorted Z-values histogram for motif FOX{D1,D2}.p2

Sorted Z-values for motif FOX{D1,D2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{D1,D2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_71551564 4.749 TSPAN8
tetraspanin 8
chr1_-_161337663 3.877 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr12_-_71551778 3.703 NM_004616
TSPAN8
tetraspanin 8
chr11_+_73359734 3.304 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr4_+_70861647 2.760 NM_001009181
NM_003154
STATH

statherin

chr10_+_51549552 2.724 NM_002443
NM_138634
MSMB

microseminoprotein, beta-

chr5_+_78531848 2.669 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr17_+_58755158 2.618 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr14_+_56585147 2.464 PELI2
pellino homolog 2 (Drosophila)
chr14_+_56584854 2.431 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr6_+_135502521 2.235 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr17_+_9745847 2.082 GLP2R
glucagon-like peptide 2 receptor
chr9_-_3223007 1.861


chr1_+_151630710 1.860 SNX27
sorting nexin family member 27
chr6_+_135502445 1.856 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr6_+_135502477 1.833 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr3_+_113616317 1.819 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr7_-_95225802 1.782 NM_002612
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr10_+_95848811 1.759 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr1_+_227127959 1.746 ADCK3
aarF domain containing kinase 3
chr1_+_20512577 1.746 NM_152376
UBXN10
UBX domain protein 10
chr11_-_34535302 1.727 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr13_-_39564857 1.711 NM_001144033
NM_145286
STOML3

stomatin (EPB72)-like 3

chr6_-_29527701 1.696 NM_006398
UBD
ubiquitin D
chr1_+_227127993 1.686 ADCK3
aarF domain containing kinase 3
chr3_-_167098070 1.641 NM_001199202
NM_001199201
NM_024687
ZBBX


zinc finger, B-box domain containing


chr1_+_227127999 1.629 ADCK3
aarF domain containing kinase 3
chr2_+_97481977 1.621 NM_017623
NM_199078
CNNM3

cyclin M3

chr10_-_99094427 1.603 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr4_+_41700736 1.599 LIMCH1
LIM and calponin homology domains 1
chr17_+_68071386 1.589 NM_018658
NM_170741
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr10_+_99079017 1.586 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr3_+_181429711 1.534 NM_003106
SOX2
SRY (sex determining region Y)-box 2
chr8_+_40010986 1.510 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr1_+_227127937 1.487 NM_020247
ADCK3
aarF domain containing kinase 3
chr8_-_133772808 1.462 NM_001145153
NM_144649
TMEM71

transmembrane protein 71

chr1_+_40862471 1.389 NM_001198980
SMAP2
small ArfGAP2
chr1_-_60392324 1.352 NM_000775
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr5_-_110062365 1.342 NM_001039763
TMEM232
transmembrane protein 232
chr17_+_72732958 1.339 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr1_-_60392461 1.313 CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr11_-_102826433 1.302 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr11_-_115375065 1.294 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chrX_+_119029799 1.291 NM_001008534
NM_001008535
NM_178813
AKAP14


A kinase (PRKA) anchor protein 14


chr17_+_72733350 1.271 NM_001006638
NM_001163990
RAB37

RAB37, member RAS oncogene family

chr13_+_50589389 1.271 NM_173605
NM_199464
TRIM13
KCNRG

tripartite motif containing 13
potassium channel regulator

chr18_-_53303129 1.251 NM_001243226
TCF4
transcription factor 4
chr1_+_87794548 1.236 LMO4
LIM domain only 4
chr18_-_53257033 1.229 NM_001243227
NM_001243228
TCF4

transcription factor 4

chr9_-_3525721 1.202 RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr4_-_70518964 1.200 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr17_-_6947241 1.200 NM_153357
SLC16A11
solute carrier family 16, member 11 (monocarboxylic acid transporter 11)
chr19_+_859658 1.199 NM_001928
CFD
complement factor D (adipsin)
chr19_+_859673 1.198 CFD
complement factor D (adipsin)
chr4_-_100356290 1.189 NM_001166504
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr14_-_36982976 1.182 NM_001101341
SFTA3
surfactant associated 3
chr1_-_207095198 1.143 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr5_-_42811959 1.141 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr4_-_141075232 1.134 NM_018717
MAML3
mastermind-like 3 (Drosophila)
chr11_-_114466397 1.133 FAM55D
family with sequence similarity 55, member D
chr9_-_37465384 1.113 NM_014872
ZBTB5
zinc finger and BTB domain containing 5
chr9_-_98269686 1.106 NM_001083606
PTCH1
patched 1
chr2_+_12856813 1.105 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr11_-_26593667 1.094 NM_001135091
NM_001135092
NM_145650
MUC15


mucin 15, cell surface associated


chr3_-_93692898 1.092 NM_000313
PROS1
protein S (alpha)
chr17_+_72427535 1.075 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr22_-_31686707 1.066 PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr3_-_93692592 1.061 PROS1
protein S (alpha)
chr18_-_53071225 1.061 NM_001243232
TCF4
transcription factor 4
chr14_-_76447445 1.060 TGFB3
transforming growth factor, beta 3
chr20_+_48429375 1.047 SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr6_+_139094656 1.037 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr20_+_48429249 1.032 NM_015266
SLC9A8
solute carrier family 9 (sodium/hydrogen exchanger), member 8
chr8_-_40755328 1.029 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr9_-_94124194 1.003 NM_001698
AUH
AU RNA binding protein/enoyl-CoA hydratase
chr1_+_246729818 0.999 CNST
consortin, connexin sorting protein
chr6_+_89791510 0.996 PNRC1
proline-rich nuclear receptor coactivator 1
chr21_-_43735462 0.996 TFF3
trefoil factor 3 (intestinal)
chr1_+_12806162 0.995 NM_152290
C1orf158
chromosome 1 open reading frame 158
chr11_+_62104773 0.987 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chr11_+_13299329 0.979 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr1_+_246729803 0.973 CNST
consortin, connexin sorting protein
chr14_-_76448091 0.968 NM_003239
TGFB3
transforming growth factor, beta 3
chr3_+_23987514 0.964 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr10_-_45474210 0.963 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr19_-_50316360 0.958 NM_001171937
NM_025129
FUZ

fuzzy homolog (Drosophila)

chrX_-_108725284 0.944 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr2_+_191301020 0.943 MFSD6
major facilitator superfamily domain containing 6
chr6_+_149068148 0.940 NM_005715
UST
uronyl-2-sulfotransferase
chr3_-_3221361 0.934 CRBN
cereblon
chr3_-_3221385 0.922 CRBN
cereblon
chr3_-_48956817 0.921 NM_001123040
C3orf71
chromosome 3 open reading frame 71
chr1_+_246729638 0.918 NM_001139459
NM_152609
CNST

consortin, connexin sorting protein

chr13_-_86373328 0.916 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr3_-_19975671 0.909 NM_144715
EFHB
EF-hand domain family, member B
chr12_+_12764755 0.901 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr11_+_13299349 0.900 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr10_-_21435487 0.896 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr9_-_98269480 0.896 NM_001083607
PTCH1
patched 1
chr1_+_145438437 0.892 NM_006472
TXNIP
thioredoxin interacting protein
chr11_+_13299372 0.891 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr5_-_16509106 0.884 NM_019000
FAM134B
family with sequence similarity 134, member B
chrX_+_70315637 0.881 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr17_-_6735007 0.879 NM_053285
TEKT1
tektin 1
chr11_+_13299376 0.877 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr11_-_72504643 0.873 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr2_-_71454200 0.872 NM_020459
PAIP2B
poly(A) binding protein interacting protein 2B
chr7_-_6098813 0.850 NM_001134335
NM_014413
EIF2AK1

eukaryotic translation initiation factor 2-alpha kinase 1

chr4_-_2263706 0.846 NM_006454
MXD4
MAX dimerization protein 4
chr14_+_105266878 0.844 NM_001137601
ZBTB42
zinc finger and BTB domain containing 42
chr3_+_171561138 0.843 NM_001164436
TMEM212
transmembrane protein 212
chr11_+_13299260 0.837 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr4_+_86396251 0.834 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr20_+_23015949 0.831 NM_001052
SSTR4
somatostatin receptor 4
chr3_+_151488214 0.824 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr4_+_134073180 0.822 PCDH10
protocadherin 10
chr7_+_106809405 0.819 NM_001244262
NM_012257
HBP1

HMG-box transcription factor 1

chr9_-_3525973 0.814 NM_002919
NM_134428
RFX3

regulatory factor X, 3 (influences HLA class II expression)

chr2_+_189157551 0.809 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr6_-_30043547 0.797 NM_170769
NM_025236
RNF39

ring finger protein 39

chr14_-_21493910 0.791 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr11_-_85397215 0.789 NM_152723
CCDC89
coiled-coil domain containing 89
chr5_+_140186658 0.787 NM_018907
NM_031500
PCDHA4

protocadherin alpha 4

chr6_-_29527477 0.786 UBD
ubiquitin D
chr22_-_31688329 0.780 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr14_-_21493858 0.776 NDRG2
NDRG family member 2
chr4_-_123542165 0.769 NM_001207006
NM_021803
IL21

interleukin 21

chr2_-_87303105 0.769 LOC285074
anaphase promoting complex subunit 1 pseudogene
chr19_+_18111923 0.768 NM_001025604
ARRDC2
arrestin domain containing 2
chr17_+_57408907 0.765 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr19_-_47734215 0.764 NM_014417
BBC3
BCL2 binding component 3
chr2_-_160472960 0.762 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr14_-_74551073 0.762 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr9_-_94124149 0.759 AUH
AU RNA binding protein/enoyl-CoA hydratase
chr2_+_71162995 0.751 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr16_-_1832576 0.751 NM_080861
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr22_-_38902281 0.749 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr14_-_91526912 0.744 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr1_-_45956795 0.738 NM_007170
TESK2
testis-specific kinase 2
chr7_+_134832765 0.738 NM_018295
TMEM140
transmembrane protein 140
chr3_-_3221390 0.737 NM_001173482
NM_016302
CRBN

cereblon

chr1_+_87794576 0.736 LMO4
LIM domain only 4
chr1_-_1356823 0.733 NM_001145210
NM_001243535
NM_001243536
ANKRD65


ankyrin repeat domain 65


chr17_-_46035109 0.708 NM_024320
PRR15L
proline rich 15-like
chr14_-_74551159 0.701 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chrX_-_10851808 0.698 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_33722158 0.696 NM_152493
ZNF362
zinc finger protein 362
chr4_-_105416050 0.696 CXXC4
CXXC finger protein 4
chr4_-_103682126 0.691 MANBA
mannosidase, beta A, lysosomal
chr13_-_49975734 0.691 NM_030925
CAB39L
calcium binding protein 39-like
chr5_+_36608430 0.687 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_+_97874704 0.684 MBNL2
muscleblind-like 2 (Drosophila)
chr10_-_21186530 0.677 NM_006393
NEBL
nebulette
chr3_-_112693711 0.676 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr1_+_87797371 0.675 LMO4
LIM domain only 4
chr13_+_111367328 0.667 NM_005537
ING1
inhibitor of growth family, member 1
chr15_-_60884615 0.664 NM_134262
RORA
RAR-related orphan receptor A
chr14_+_24584321 0.662 DCAF11
DDB1 and CUL4 associated factor 11
chr14_+_24584467 0.661 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr14_+_24584009 0.660 DCAF11
DDB1 and CUL4 associated factor 11
chr11_+_111385509 0.660 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr16_-_1832571 0.660 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr1_+_246729724 0.651 CNST
consortin, connexin sorting protein
chr1_+_111889194 0.651 NM_181643
C1orf88
chromosome 1 open reading frame 88
chr1_+_244214552 0.641 NM_205768
ZNF238
zinc finger protein 238
chr3_+_23986735 0.635 NM_005126
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr10_+_111985628 0.632 NM_005962
MXI1
MAX interactor 1
chr9_-_136933091 0.631 NM_007371
BRD3
bromodomain containing 3
chr5_+_121465214 0.629 NM_207317
ZNF474
zinc finger protein 474
chr11_-_66335958 0.628 NM_003793
CTSF
cathepsin F
chr7_+_91570150 0.625 NM_005751
NM_147185
AKAP9

A kinase (PRKA) anchor protein (yotiao) 9

chr7_+_94539209 0.619 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr19_+_50380681 0.619 NM_001168222
NM_024682
TBC1D17

TBC1 domain family, member 17

chr3_-_141868208 0.616 NM_001178138
NM_001178139
TFDP2

transcription factor Dp-2 (E2F dimerization partner 2)

chr19_+_35630391 0.613 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr3_-_125820390 0.613 NM_001164475
SLC41A3
solute carrier family 41, member 3
chrX_+_9431314 0.612 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr2_+_111878450 0.608 NM_001204106
NM_001204107
NM_001204108
NM_001204109
NM_001204110
NM_001204111
NM_001204112
NM_001204113
NM_006538
NM_138621
NM_138622
NM_138623
NM_138624
NM_138625
NM_138626
NM_138627
NM_207002
NM_207003
BCL2L11

















BCL2-like 11 (apoptosis facilitator)

















chrX_+_54834107 0.607 NM_177433
MAGED2
melanoma antigen family D, 2
chr10_+_111969988 0.602 NM_001008541
MXI1
MAX interactor 1
chr19_+_13906207 0.599 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr14_+_24583979 0.599 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr15_-_44828864 0.596


chr10_-_105992062 0.595 NM_025145
WDR96
WD repeat domain 96
chr14_+_24583905 0.594 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr20_+_62887046 0.592 NM_001104925
NM_018257
PCMTD2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr1_+_161136180 0.586 NM_000309
NM_001122764
PPOX

protoporphyrinogen oxidase

chr16_-_84150381 0.585 MBTPS1
membrane-bound transcription factor peptidase, site 1
chr6_-_79944397 0.579 NM_001201362
NM_001201363
NM_004242
NM_138730
HMGN3



high mobility group nucleosomal binding domain 3



chr4_+_106067031 0.577 NM_017628
TET2
tet methylcytosine dioxygenase 2
chr12_-_92539614 0.576 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr3_+_64670779 0.574 ADAMTS9-AS2
ADAMTS9 antisense RNA 2 (non-protein coding)
chr6_-_79944324 0.567 HMGN3
high mobility group nucleosomal binding domain 3
chr1_-_92351476 0.567 TGFBR3
transforming growth factor, beta receptor III
chr2_+_149402559 0.563 NM_015630
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr16_+_84150634 0.562 LOC729887
uncharacterized LOC729887
chr4_-_151770611 0.556 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr16_-_28550227 0.553 NUPR1
nuclear protein, transcriptional regulator, 1
chr17_+_57642885 0.550 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr3_-_15839674 0.548 NM_001195098
ANKRD28
ankyrin repeat domain 28

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.97 2.07e-04 GO:0009890 negative regulation of biosynthetic process
1.98 2.08e-04 GO:0031327 negative regulation of cellular biosynthetic process
2.01 2.21e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
2.00 4.92e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.29 4.97e-04 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
2.02 2.26e-03 GO:0045892 negative regulation of transcription, DNA-dependent
1.72 2.48e-03 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.93 3.63e-03 GO:0010629 negative regulation of gene expression
1.98 4.19e-03 GO:0051253 negative regulation of RNA metabolic process
1.91 5.73e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.88 8.45e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.71 1.00e-02 GO:0031324 negative regulation of cellular metabolic process
1.63 3.81e-02 GO:0009892 negative regulation of metabolic process
2.53 4.46e-02 GO:0032582 negative regulation of gene-specific transcription
1.64 4.95e-02 GO:0010605 negative regulation of macromolecule metabolic process

Nothing significant found in compartment category.

Nothing significant found in function category.